Patch Clamping: An Introductory Guide to Patch Clamp Electrophysiology Review

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Patch Clamping: An Introductory Guide to Patch Clamp Electrophysiology ReviewSimply put, this is the best (and in my search, the only) introductory patch clamp guide available. I sought out this book after reading several patch clamp guides that offered little or no help in the fundamental understanding of patch clamp methods. Books such as "Introduction to Electrophysiological Methods and Instrumentation", "The Axon Guide", and "Patch-Clamp Analysis: Advanced Techniques" are beyond the scope of the beginner electrophysiologist and are written for researchers with some electrophysiology experience, and with a heavy electrical engineering slant. Others such as "Patch-Clamp Methods and Protocols" are just that... a series of protocols that read as if they are taken directly out of a methods journal. Again, this is great if one is already practicing patch clamp and is looking to expand one's skill set. So after reading all four of these books, I still felt fundamentally frustrated with the explanations of the different methods and still recognized a general lack of fundamental information presented in a simplified perspective. I thought I would give "Patch Clamping: An introductory guide to Patch Clamp Electrophysiology" a last chance effort before giving up on finding a "good" patch clamp book. It paid off. This is quite simply the best intro to patch clamp I have read... and probably the only one currently available. If there is another good intro to patch clamp book out there, I was unable to find it. This book is a "must have" to all who are just starting out in patch clamp. I might also mention that "Patch clamp analysis: advanced techniques" is also not a bad book to have in the lab, but should be read AFTER reading "Patch Clamping" AND after several months of hands on patch clamp experience. Highly Recommended!Patch Clamping: An Introductory Guide to Patch Clamp Electrophysiology OverviewPatch clamping is a widely applied electrophysiological technique for the study of ion channels; membrane proteins that regulate the flow of ions across cellular membranes and therefore influence the physiology of all cells.Patch Clamping aims to cover the basic principles and practical applications of this important technique. Starting with a review of the history of patch clamping, the text then goes on to cover the basic principles, platforms, equipment and environmental control, and will also include coverage of preparation types, recording modes and analysis of results.* This book will explain the basic principles and practical application of patch clamp electrophysiology.* Written in a non-technical style to ensure its broad appeal to novice users* Takes a practical approach* This self-contained guide provides everything a practising patch clamp electrophysiologist needs to know to master this technique, including an overview of membrane biophysics, standard experimental design, data analysis, and technical concerns

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