Excitation-Contraction Coupling and Cardiac Contractile Force (Developments in Cardiovascular Medicine) Review

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Excitation-Contraction Coupling and Cardiac Contractile Force (Developments in Cardiovascular Medicine) ReviewHere it is! The second edition of the classic "Bers book". Still easy to read, up to date information with many new references and a whole new chapter on action potential & ion channels in the heart. It is longer that the first edition but still focused including more than 170 excellent figures. The new edition is even more valuable than the first one, not only for students, Post-Docs, but also for experienced researchers. It is a must read for everyone who works in the field of heart research (physiology, electrophysiology, molecular biology, pathophysiology etc.). This is the reason why it is generally accepted a classic and - without question - deserves all five stars. Thank you Don Bers!Excitation-Contraction Coupling and Cardiac Contractile Force (Developments in Cardiovascular Medicine) OverviewHow is the heartbeat generated? What controls the strength ofcontraction of heart muscle? What are the links between cardiacstructure and function? How does our understanding of skeletal andsmooth muscle and non-muscle cells influence our thinking about forcedevelopment in the heart? Are there important species differences inhow contraction is regulated in the heart? How do the new moleculardata fit together in understanding the heart beat? What goes wrong inischemia, hypertrophy, and heart failure? This book paints a modern`portrait' of how the heart works and in this picture the author showsa close-up of the structural, biochemical, and physiological linksbetween excitation and contraction. The author takes the reader through a series of important,interrelated topics with great clarity and continuity and alsoincludes many useful illustrations and tables. The book starts byconsidering the cellular structures involved inexcitation-contraction coupling and then described thecharacteristics of the myofilaments as the end effector ofexcitation-contraction coupling. A general scheme of calciumregulation is described and the possible sources and sinks of calciumare discussed in simple, but quantitative terms. The cardiac actionpotential and its many underlying currents are reviewed. Then thecharacteristics of some key calcium transport systems (calciumchannels, sodium/calcium exchange and SR calcium uptake and release)are discussed in detail. This is then built into a more integratedpicture of calcium regulation in succeeding chapters by detaileddiscussions of excitation-calcium coupling mechanisms (inskeletal, cardiac, and smooth muscle), the interplay between calciumregulatory processes, and finally mechanisms of cardiac inotropy,calcium overload, and dysfunction (e.g., ischemia, hypertrophy, andheart failure). Excitation-Contraction Coupling and Cardiac ContractileForce &endash; Second Edition is an invaluable source ofinformation for anyone who is interested in how the heart beat iscontrolled and especially suited for students of the cardiovascularsystem at all levels from medical/graduate students through seniorinvestigators in related fields.

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